会议目录

致辞嘉宾

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吴爱华

中国仪器仪表学会分析仪器分会秘书长

个人简介:

       中国仪器仪表学会分析仪器分会,秘书长,兼任中国仪器仪表学会科学仪器学术工作委员会副秘书长;科技部“重大科学仪器设备开发重点专项”2016-2020年指南编制专家组成员,主持完成仪器行业及市场研究报告50余份。

 

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朱岩

中国仪器仪表学会分析仪器分会离子色谱专家组主任委员

个人简介:

       浙江大学化学系教授、博士生导师。已经发表离子色谱相关论文300多篇,其中SCI收录近200篇,获授权专利40余项和省部级以上奖励10余项。中国仪器仪表学会分析仪器分会离子色谱专家组主任委员,《分析试验室》副主篇,《色谱》、《中国无机分析化学杂志》编委。

 

报告专家

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李响

中国食品药品检定研究院 研究员

个人简介:

       2002年进入中国食品药品检定研究院工作至今。研究方向为重组DNA制品的质量控制,核酸和多肽药物、基因治疗药物质量和技术研究,重组细胞因子标准品的建立及应用研究。创新药物研究开发技术平台建设等。

报告内容:离子色谱在重组药物糖基化分析中的应用

内容亮点:

1.重组药物糖基化分析的目的和策略

糖基化是蛋白质一种重要的翻译后修饰:大多数重组药物功能的实现与其糖基化修饰密切相关,糖基化修饰会影响蛋白的性能,如构象、稳定性、溶解度、药物代谢动力学、活性及免疫原性。其中N糖研究的最多。

2.重组应用高效阴离子交换色谱-脉冲安培检测法(HPAEC-PAD)分析重组药物的寡糖

 

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Bethany Jackson

Senior Scientist, Astra Zeneca, UK

个人简介:

      Bethany Jackson is an experienced Senior Scientist at AstraZeneca UK working in Pharmaceutical Technology and Development. She has been leading the Ion Chromatography development for the past five years. This led to multiple development projects in the area of polar molecule analysis, including implementing IC-MS technology within the department. Recently, she has been involved in ongoing nitrosamine risk mitigation activities resulting in the analysis of trace secondary amines and nitrites.

报告题目:Ion Chromatography for Pharmaceutical Impurity Analysis

Part 1: Challenges and Advantages of Using IC-MS in the Pharmaceutical Industry

内容亮点:

This webinar will explore how by adding a mass spectrometer to an ion chromatograph, it becomes possible to confirm and identify any of the unknowns in a pharmaceutical compound. Troubleshooting processes to prevent unwanted impurities in the final drug will also be covered, using nitrosamine as an example.

 

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Jeffrey Rohrer

Director of Applications Development
Thermo Fisher Scientific

个人简介:

      Jeffrey Rohrer is Director of Applications Development, Dionex Products for Thermo Fisher Scientific. He received his Ph. D. in Chemistry from the University of Delaware. Dr. Rohrer is an author of 80 peer-reviewed publications and a member of the United States Pharmacopeia’s Chemical Medicines 1 Expert Committee.

报告题目:Ion Chromatography for Pharmaceutical Amines

内容亮点:

When an analyst is charged with quantifying the amount of an amine in a pharmaceutical sample, they often choose GC or HPLC, forgetting that amines are cations in even slightly alkaline solutions and therefore can be determined by ion chromatography (IC). IC offers several advantages for determining amines. Sample derivatization is never required thereby eliminating that time, expense, and waste. The mobile phase required for separation can be automatically prepared by an eluent generator, freeing the analyst to do other lab tasks and eliminating a source of error. A mass spectrometer can easily be added as a second mode of detection to confirm the presence of an amine or help identify an unknown amine. This presentation shows how IC has been used to determine amine impurities in pharmaceutical samples and assay amines that are drug substances or the active ingredients in drug products.

 

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李春华

集成电路产业计量检测创新中心 主任

个人简介:

       李春华,华东理工大学材料科学与工程专业毕业,研究生硕士,高级工程师。2009年3月参加工作,现任上海市计量测试技术研究院集成电路产业计量检测创新中心主任兼上海市电子化学品计量检测技术服务平台技术主管。担任全国化学标准化技术委员会化学试剂分会委员,至今已参与起草国家标准10余项。

从事检测分析13年,在痕量和超痕量杂质检测方面富有经验,熟悉电子化学品中元素的方法学开发和验证工作。所属实验室在湿电子化学品、电子级多晶硅、硅片、光刻胶、抛光液、金属靶材和电子级气体领域已通过CNAS和CMA认证。

报告内容:离子色谱技术在集成电路产业的应用

内容亮点:

离子色谱技术在集成电路产业主要应用于材料中痕量杂质的检测,特别是痕量阴离子的定量检测。报告中介绍离子色谱在集成电路6种材料的应用实例。分别为:超纯水中20ppt阴离子浓缩技术,有机试剂中1ppb阴离子检测,氢氟酸检测中排斥柱技术,光刻胶中燃烧炉技术,电子特气吸收法的应用,碱性样品的二次中和技术。

 

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Anna Wolna

Sr. Scientist, Phillips 66

个人简介:

      Anna completed her Ph.D. in Chemistry at University of Utah and then joined Phillips 66 in 2014. Her work focuses on analytical method development, validation, and deployment as well as performing analytical forensics while troubleshooting refinery issues. She has experience working at Energy Research and Innovation center (Oklahoma) and at Sweeny Refinery (Texas) laboratories. During her tenure with Phillips 66, she had an opportunity to work with IC, ICP, XRF, GC and various wet chemistry methods and instrumentation.

 

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Heather Hunsucker

Research Scientist, Phillips 66

个人简介:

      Heather has been in Analytical Support and Research at Phillips 66 for 8 years, most of which involved working with ion chromatography (IC) instrumentation. During that time, she has assisted in developing new methods, supporting research in the IC lab, and using IC techniques to troubleshoot refinery issues.

 

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Libby Brader

Research Scientist, Phillips 66

个人简介:

      Libby has worked at Phillips 66 in Analytical Support and Research for 7 years; the first years were spent in the ICP-MS lab testing for metals and the remaining 5 years have been working with the IC. Using the different analytical techniques, she looks for ions and metals that will help diagnose refinery problems, helps to develop new methods, and provides support for the many research projects happening throughout Phillips 66. 

报告题目:Ion Chromatography: Enabling Value for the Petroleum Industry

内容亮点:

Ion chromatography (IC) provides a powerful means of measuring ions in a variety of samples. At first glance, the oil and gas industry might not be identified as a heavy user of such instrumentation, however, being able to accurately determine ion concentrations in a variety of sample types is critical for monitoring quality and risks associated with oil and gas refining.

 

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蔡亚岐

中国科学院生态环境研究中心 研究员

个人简介:

       蔡亚岐,研究员,中国科学院生态环境研究中心。主要从事环境化学和色谱-质谱分析研究,重点关注全氟/多氟化合物、甲基硅氧烷、有机磷酸酯等新型有机污染物分析及其环境行为、纳米材料制备及环境和分析化学应用等。先后主持完成多项国家863课题、国家自然科学基金、国家重点研发计划课题、中国科学院大型仪器研制项目、中国科学院先导性项目课题、国家环保公益性行业科研专项等项目。在Environ. Sci. Technol., Anal. Chem., Chem. Com., J. Mater. Chem. A,Appl. Catal. B: Environ.等SCI收录期刊发表论文160余篇,论文SCI他引12000余次;主编或参编专著6部。作为主要成员先后于2018(排名第二)和2011(排名第四)年两次获得国家自然科学二等奖;作为主要完成人获得中国科学院杰出科技成就奖

报告内容:离子色谱在环境科研领域的应用新进展

内容亮点:

从环境分析的角度出发,介绍离子色谱特别是高压离子色谱技术的进展和应用。重点关注离子色谱在具有重要环境科学意义的砷、磷等元素的形态分析、全氟/多氟化合物分析方面的研究进展,也关注在糖类、核苷酸类等具有生物和“双碳”研究等相关研究方面的应用。在其中高度重视复杂基体样品中微量微量多组分目标物的同时分析。

 

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Prof. Brett Paull

Associate Dean (Research), University of Tasmania

个人简介:

      Professor Paull is based within the Australian Centre for Research on Separation Science (ACROSS) at the University of Tasmania. Prof. Paull’s research interests lie in the development and characterization of advanced materials for application within the analytical sciences, and the development of advanced methods and technologies for industrial and environmental analysis. Prof. Paull’s research is detailed within over 330 published research articles, papers and book chapters/books, which collectively have been cited over 9,500 times to-date (GS).

报告题目:The Power of IC Coupled with Triple Quad Mass Spectrometry to Study Ionic Content and Speciation of Water Samples

内容亮点:

The coupling of modern high-performance suppressed ion chromatography with advanced mass spectrometry is a powerful solution to many complex environmental and industrial problems, specifically those requiring qualitative and quantitative understanding of the ionic complexity within such samples. For the past number of years, we have been exploring the power of ion chromatography coupled with triple quadrupole mass spectrometry to study the ionic content and speciation of environmental and industrial water samples and extracts, engaging in collaborative projects spanning aquacultural systems, biomarkers for climate change, natural product characterization and mine processing. The results and conclusions of our work confirm to us how this combination of technologies has a great future in the analytical lab and much to offer going forward in the field of ion analysis. 

 

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刘玉峰

北京市营养源研究所有限公司 研究员

个人简介:

       刘玉峰,北京市营养源研究所有限公司分析检测中心副主任,研究员,主要从事食品中营养成分的分析检测技术研究开发,参与完成了科技部支撑项目、北京市科技新星计划、卫生部等10余项课题研究,参与编写论著4部。参与制定国家标准8项,行业标准4项,团体标准2项,荣获北京市科学技术研究院优秀成果奖1项,北京市丰台区科学技术二等奖1项,大北农科技奖创意奖1项,河北省科学技术进步奖三等奖1项。

报告内容:离子色谱在食品糖类分析检测中的应用研究

内容亮点:

离子色谱-安培检测器以其分离度好,灵敏度高、不需要衍生等特性在食品中糖类的分析测试方面不断凸显其优越性,在糖类的定性定量方面开启了一个新的局面。近年来,我国食品安全国家标准也逐渐引入了离子色谱法,本讲座主要介绍离子色谱在食品糖类检测方面的应用研究,探讨离子色谱的应用前景。

  

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Thales de Freitas Costa

Head Engineer, Faculty of Chemistry, Biotechnology and Food Science, NMBU, Norwegian University of Life Sciences

个人简介:

      Thales is a Biochemist trained in Enzymology and Bioprocessing technology by the University of São Paulo. He was first introduced to chromatography instrumentation as an undergraduate and expanded his experience by utilizing chromatographic carbohydrate analysis as his main tool during his postgraduate studies. In 2016 he joined The Protein Engineering and Proteomics research group at the Norwegian University of Life Sciences, gaining experience in Ion Chromatography and many other types. Four years later he became the Research Engineer in the group, supporting IC and HPLC users.

报告内容:Chromatographic Analysis of Oxidized Cello-oligomers Generated by LPMOs Using Dual Electrolytic Eluent Generation

内容亮点:

Lytic polysaccharide monooxygenases (LPMOs) have been gaining a major interest in the bioprocessing of lignocellulose, and the ability to efficiently and accurately separate and quantify their native and oxidized products chromatographically is essential in furthering our understanding of these oxidative enzymes. A new ion chromatography method has been developed in our group and it is based on dual electrolytic eluent generation, where the conventional sodium acetate/sodium hydroxide (NaOAc/NaOH) eluents in high-performance anion-exchange chromatography (HPAEC) are replaced by electrolytically-generated potassium methane sulfonate/potassium hydroxide (KMSA/KOH). The new methods separate all compounds of interest within 24–45 min and with high sensitivity. This new chromatographic platform also overcomes drawbacks associated with manual preparation of eluents and offers simplified operation and rapid method optimization, with increased precision for less abundant LPMO-derived products.


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