2020年6月1日美国马萨诸塞州比勒里卡 --在ASMS 2020网络大会上发布了世界上第一个商用MALDI后电离（PI）离子源MALDI-2。现在MALDI-2 离子源作为选配项可用于timsTOF fleX™ ESI / MALDI质谱仪上。全新的MALDI-2离子源可将小分子和脂质分析的灵敏度提高一到两个数量级，从而进一步扩大MALDI质谱与基于MALDI技术的质谱成像应用范围。

此外，布鲁克还推出了基于TIMS / PASEF的4D-蛋白质组学新方法，包括全新的PRM方法prm-PASEF®、短梯度DIA方法dia-PASEF®、4D数据采集与分析MOMA（Mobility Offset Mass Aligned）以及基于GPU实时数据搜索引擎的“Run & Done”数据分析方法。4D-蛋白质组学每次样本分析能产生成千上万条多肽的精确CCS （碰撞横截面积）值，这些新的方法都是基于对这些精确的CCS值的大规模并实时利用，从而大大提高蛋白、多肽和PTMs鉴定的深度和可靠性，除此之外，CCS值创新性的使用，也为LFQ分析带来了超稳定和超高灵敏度的性能，并在timsTOF Pro这一极其稳定的质谱平台上实现了真正高通量4D-蛋白质组学、4D-脂质组学和4D-代谢组学。

本次讲座将详细介绍2020年ASMS期间布鲁克发布的最新质谱技术及前沿应用。

Key Speakers:

What‘s New with Bruker（25min）1:30-1:55pm

Rohan Thakur, PhD, Managing Director and Executive Vice President, Life Sciences Mass Spectrometry, Bruker Daltonik GmbH, Bremen, Germany

The Synergies of Mass Spectrometry and Informatics（25min）1:55-2:20pm

Prof. John Yates, PhD, The Scripps Research Institute, Molecular Medicine, La Jolla, CA, USA

Next level imaging Mass Spectrometry: Single cells in focus with SpatialOMx（25min）2:20-2:45pm

Prof. Ron Heeren, PhD, Maastricht University, Division Head Imaging MS, Maastricht, Netherlands

Featured Speakers Proteomics/BioPharma Session

Advances in 4D-Proteomics with the timsTOF Pro: PASEF, dia-PASEF, prm-PASEF, MOMA, and RTMS（30min）2:45-3:15pm

Gary H. Kruppa, PhD, Vice President Proteomics, Bruker Daltonics, Billerica, MA, USA

Clinical Proteomics in interesting times（30min）3:15-3:45pm

Roman Fischer, PhD, Associate Professor and Head of Discovery Proteomics Facility, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

Developing PRM on the timsTOF Pro for biomarker studies in cerebrospinal fluid（15min）3:45-4:00pm

Jarrod Marto, PhD, Associate Professor Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

Human leukocyte antigen II immunopeptidomics in dendritic cells in response to immune-complexes of TNF with anti-TNF biotherapeutics（20min）4:00-4:20pm

Andrea Casasola-LaMacchia, PhD, Postdoctoral Fellow, Immunogenicity, Biomedicine Design and Hendrik Neubert, PhD, Senior Director Biomeasures, Dynamics and Metabolism Department, Pfizer, New York, NY, USA

Featured Speakers spatialOMx/Imaging Session

Introducing the timsTOF fleX with MALDI-2 （20min）4:20-4:40pm

Michael L. Easterling, PhD, Global MS Imaging Director, Bruker Daltonics, Billerica, MA, USA

High-speed MALDI-2 on a timsTOF fleX: An overview of applications（20min）4:40-5:00pm

Dr.Bram Heijs, Head Mass Spectrometry Imaging Group, Center for Proteomics & Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

Application of SpatialOMx for the discovery of biomarkers of hepatocellular carcinoma（30min）5:00-5:30pm

Prof. Anand Mehta, PhD, Cell and Molecular Pharmacology and Experimental Therapeutics, College of Medicine, Medical University of South Carolina, Charleston, SC, USA

Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS): A Multiplexed Microarray Platform for Targeted Proteomics （20min）5:30-5:50pm

Ghaith Hamza, PhD, Proteomics Specialist , Astra Zeneca, BioPharmaceuticals R&D, Discovery Science, MA, USA